CVE-2026-31963 HIGH

CVE-2026-31963: HTSlib CRAM reader has heap buffer overflow due to improper validation of input

Vendor Samtools
Product htslib
Weakness CWE-122
Published March 18, 2026
Last update March 18, 2026

CVSS base score

8.8/10
Attack vector Network
Attack complexity Low
Privileges required None
User interaction None
Confidentiality
Integrity

CVSS vector

CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:L/SC:N/SI:N/SA:N

What the vulnerability does

01Description

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full sequence for each alignment record it stores a location in an external reference sequence along with a list of differences to the reference at that location as a sequence of "features". When decoding these features, an out-by-one error in a test for CRAM features that appear beyond the extent of the CRAM record sequence could result in an invalid write of one attacker-controlled byte beyond the end of a heap buffer. Exploiting this bug causes a heap buffer overflow. If a user opens a file crafted to exploit this issue, it could lead to the program crashing, or overwriting of data and heap structures in ways not expected by the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Key dates

02Disclosure timeline

March 18, 2026 CVE published
March 18, 2026 Record updated